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Jun 14, 2015 · In vivo studies indicate that Mangradex formulations are safe and show no nephrotoxic effects after chronic exposure at doses ≤ 50 mg/kg. MRI ...
Lee S., Kanakia S., Toussaint J., Kukarni P., Chowdhury S.M., Khan S., Shroyer K., Moore W., Sitharaman B.Stony Brook University, US

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Dec 2, 2015 · The results lay the foundations for further development of Mangradex as a vascular and cellular/ molecular MRI probe. Similar content being ...
Current clinical Gd3+-based T1 magnetic resonance imaging (MRI) contrast agents (CAs) are suboptimal or unsuitable, especially at higher magnetic fields (>1.5 Tesla) for advanced MRI applications such as blood pool, cellular and molecular imaging. Herein, towards the goal of developing a safe and more efficacious high field T1 MRI CA for these applications, we report the sub-acute toxicity and contrast enhancing capabilities of a novel nanoparticle MRI CA comprising of manganese (Mn2+) intercalated graphene nanoparticles functionalized with dextran (hereafter, Mangradex) in rodents. Sub-acute toxicology performed on rats intravenously injected with Mangradex at 1, 50 or 100 mg/kg dosages 3 times per week for three weeks indicated that dosages ≤50 mg/kg could serve as potential diagnostic doses. Whole body 7 Tesla MRI performed on mice injected with Mangradex at a potential diagnostic dose (25 mg/kg or 455 nanomoles Mn2+/kg; ~2 orders of magnitude lower than the paramagnetic ion concentration in a typical clinical dose) showed persistent (up to at least 2 hours) contrast enhancement in the vascular branches (Mn2+ concentration in blood at steady state = 300 ppb, per voxel = 45 femtomoles). The results lay the foundations for further development of Mangradex as a vascular and cellular/ molecular MRI probe.

... Mangradex) in rodents. Sub-acute toxicology performed on rats intravenously injected with Mangradex at 1, 50 or 100 mg/kg dosages 3 times per week for three ...
AbstractCurrent clinical Gd3+-based T₁ magnetic resonance imaging (MRI) contrast agents (CAs) are suboptimal or unsuitable, especially at higher magnetic fields (>1.5 Tesla) for advanced MRI applications such as blood pool, cellular and molecular imaging. Herein, towards the goal of developing a safe and more efficacious high field T₁ MRI CA for these applications, we report the sub-acute toxicity and contrast enhancing capabilities of a novel nanoparticle MRI C…

Aug 3, 2016 · ... Mangradex). Nephrectomized rats received single or 5 times/week ... The T1 value scans were then segmented using ITK snap (www.itksnap.org).
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The etiology of renal insufficiency includes primary (e.g polycystic kidney disease) or secondary (e.g. contrast media, diabetes) causes. The regulatory restrictions placed on the use of contrast agents (CAs) for non-invasive imaging modalities such as ...

Feb 14, 2022 · ... Mangradex a prospective MRI contrast agent. image file ... (C) A plot showing the contrast preeminence and the sustained effect of Mangradex ...
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... Mangradex) in rodents. Sub-acute toxicology performed on rats intravenously ... TechConnect Briefs 2015, TechConnect.org, ISBN 978-1-4987-4729-5 author ...
Nephrotoxicity of Dextran Functionalized Graphene Nanoparticles and Their Potential as Magnetic Imaging Contrast Agents for Renal Abnormalities

... (Mangradex) [199]. Intravenous administration of 1, 50, and 100 mg/kg dosages ... https://doi.org/10.3390/ijms21176280. AMA Style. Sharma H, Mondal S ...
The usage of nanomaterials for cancer treatment has been a popular research focus over the past decade. Nanomaterials, including polymeric nanomaterials, metal nanoparticles, semiconductor quantum dots, and carbon-based nanomaterials such as graphene oxide (GO), have been used for cancer cell imaging, chemotherapeutic drug targeting, chemotherapy, photothermal therapy, and photodynamic therapy. In this review, we discuss the concept of targeted nanoparticles in cancer therapy and summarize the in vivo biocompatibility of graphene-based nanomaterials. Specifically, we discuss in detail the chemistry and properties of GO and provide a comprehensive review of functionalized GO and GO–metal nanoparticle composites in nanomedicine involving anticancer drug delivery and cancer treatment.

Oct 13, 2022 · 13 http://phys.org/news/2016-03-revolutionary-graphene-filter-crisis ... The company unveiled its product, called ManGraDex, in June 2015.

Aug 9, 2017 · Funds will advance multi-functional imaging platform Mangradex and extend it for use for X-ray computed Tomography (CT) imaging - PR12657409.
Theragnostic Technologies Receives Phase 1 SBIR Grant from National Institutes of Health (NIH). Funds will advance multi-functional imaging platform Mangradex and extend it for use for X-ray computed Tomography (CT) imaging - PR12657409

Feb 19, 2021 · ... Mangradex nanoparticles. For example, the single- domain antibody ... 77:13-22, DOI : doi.org/10.1007/s00253-007-1142-2. 88. Hultberg et ...